The Oldham Evening Chronicle and the weekly Chronicle Weekend are to be printed at Trinity Mirror Printing from June.
The papers' current presses, owned by their publisher Hirst, Kidd and Rennie, will be closed after the switchover.
HKR said the move would allow for faster printing and more colour.
Managing director Philip Hirst said: "This has been a hard decision to take. It will be the first time that the newspaper has not had its own press since it was founded in 1854.
"However, because we are outsourcing the printing to TMP, whose plant is about a mile away, the Chronicle remains an Oldham product through and through. We are looking forward to working with TMP to improve the paper and provide Oldham with an even better news and advertising service than before."
HKR is due to launch an upmarket 15,000 circulation magazine called Fourmost to be distributed to homes in Oldham and Tameside